425 Henry Mall, Rm 4426
Joshua Coon's research group is primarily focused on instrumental developments in mass spectrometry and in proteomics to address fundamental questions in cell biology. With emphasis on ion chemistry and instrumentation, his group develops and applies new enabling mass spectrometry-based (MS) proteomic technologies. These cutting-edge tools allow them to examine the molecular events leading to cell differentiation of human embryonic stem cells and the combinatorial combination of histone post-translational modifications in pluripotent stem cells. His research interest also focuses on the development of ETD for intact protein sequencing, and on the use and application of algorithms enabling protein identification from product ion spectra. He holds several patents on ETD and its application to peptide sequencing.