Faculty

My laboratory is interested in understanding the mechanisms and regulation of mRNA processing in eukaryotic cells. We focus on understanding the steps involved in pre-mRNA splicing--the removal of introns from precursor mRNAs by the spliceosome. We use a number of techniques to study splicing including single molecule fluorescence microscopy in vitro and in human and yeast cells, molecular genetics, next generation DNA sequencing and RNA Seq, and biochemical assays.